Valsartan: The most common adverse effects include headache, dizziness, vertigo, fatigue, diarrhea, abdominal pain, muscle cramps, dry cough, hypotension, nausea, pruritus, rash, constipation, dry mouth, impotence. Other reported events seen less frequently include chest pain, syncope, anorexia, vomiting, and angioedema.
Hydrochlorothiazide: Hydrochlorothiazide and other thiazide diuretics may cause a number of metabolic disturbances especially at high doses. They may provoke hyperglycemia and glycosuria in diabetic and other susceptible patients. They may cause hyperuricemia and precipitate attacks of gout in some patients. Administration of thiazide diuretics may be associated with electrolyte imbalances including hypochloraemic alkalosis, hyponatremia, and hypokalemia.
Signs of electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain and cramps, seizures, oliguria, hypotension, and gastrointestinal disturbances.
Other side effects include anorexia, gastric irritation, nausea, vomiting, constipation, diarrhea, sialadenitis, headache, dizziness, photosensitivity reactions, orthostatic hypotension, paraesthesia, impotence, and yellow vision. Hypersensitivity reactions include skin rashes, fever, pulmonary edema, pneumonitis, anaphylaxis, and toxic epidermal necrolysis. Cholestatic jaundice, pancreatitis and blood dyscrasias including thrombocytopenia and, more rarely, granulocytopenia, leucopenia, and aplastic and haemolytic anemia have been reported.
Patient to seek medical attention immediately at the first sign of any adverse drug reaction shall appear.